Nicotinamide riboside restores cognition in Alzheimer’s.



Nicotinamide adenine dinucleotide (NAD)+, a coenzyme involved in redox activities in the mitochondrial electron transport chain, has been identified as a key regulator of the lifespan-extending effects, and the activation of NAD+ expression has been linked with a decrease in beta-amyloid (Aβ) toxicity in Alzheimer’s disease (AD). Nicotinamide riboside (NR) is a NAD+ precursor, it promotes peroxisome proliferator-activated receptor-γ coactivator 1 (PGC)-1α expression in the brain. Evidence has shown that PGC-1α is a crucial regulator of Aβ generation because it affects β-secretase (BACE1) degradation. In this study we tested the hypothesis that NR treatment in an AD mouse model could attenuate Aβ toxicity through the activation of PGC-1α-mediated BACE1 degradation. Using the Tg2576 AD mouse model, using in vivo behavioral analyses, biochemistry assays, small hairpin RNA (shRNA) gene silencing and electrophysiological recording, we found (1) dietary treatment of Tg2576 mice with 250 mg/kg/day of NR for 3 months significantly attenuates cognitive deterioration in Tg2576 mice and coincides with an increase in the steady-state levels of NAD+ in the cerebral cortex; (2) application of NR to hippocampal slices (10 μM) for 4 hours abolishes the deficits in long-term potentiation recorded in the CA1 region of Tg2576 mice; (3) NR treatment promotes PGC-1α expression in the brain coinciding with enhanced degradation of BACE1 and the reduction of Aβ production in Tg2576 mice. Further in vitro studies confirmed that BACE1 protein content is decreased by NR treatment in primary neuronal cultures derived from Tg2576 embryos, in which BACE1 degradation was prevented by PGC-1α-shRNA gene silencing; and (4) NR treatment and PGC-1α overexpression enhance BACE1 ubiquitination and proteasomal degradation. Our studies suggest that dietary treatment with NR might benefit AD cognitive function and synaptic plasticity, in part by promoting PGC-1α-mediated BACE1 ubiquitination and degradation, thus preventing Aβ production in the brain.

Could chronic facial pain and chronic diseases of inflammation be caused by your jaw bone?


Screen Shot 2015-10-11 at 9.17.32 AMThe chronic softening in the jawbone are a phenomenon that is not perceived by many areas of medicine and dentistry to date, or is not taken seriously, at least in their health effects. This “jaw-inflammation” were by the American pathologist Professor BOUQUOT as “Neuralgia Inducing Cavitational Osteonecrosis” (“neuralgia inducing cavity forming osteonecrosis = NICO) because they often cause unspecific facial pain.


Health effects of Kieferostitis

The health effects of NICO in the jaw can be condensed in two areas: on the one hand the local aspect of a chronic underlying irritation of the facial nerve. Here the symptom picture as trigeminal neuralgia is known. NICO is thus a special form of a jawbone disease – based on facial pain and trigeminal neuralgia. On the other hand, the systemic failure of important organs or cell function by releasing their inflammatory neurotransmitters, which are demonstrated in NICO areas. This shows a much less clear, but a confusing picture of the diverse symptoms NICO effect.

This bone disease have an impact on the overall system in terms of a silent chronic inflammation: The easily comprehensible term “NICO” has yet naturalized internationally in clinical parlance. This, and the non-visibility on conventional radiographs – “NICO does not exist” – makes the study of the chronic Kieferostitis / NICO not easier, but requires everyone involved scientific openness and probable cause search in a particular case of the patient concerned.

Screen Shot 2015-10-11 at 9.17.50 AMProblems of Jaw ostitis diagnostics

To disregard the NICO as sickening change the jawbone certainly bears the problem of their X-ray presentation at: A normal X-ray image does not show the NICO or only very limited!
The introduction of digital volume tomography (DVT), a method is available which represents the structures in a NICO with greater reliability. We serve for the special bone densitometry in the jaw designed CaviTAU ultrasound system as an additional imaging procedure for the metrological determination of bone density and to hedge the previous X-ray diagnostics. For the purposes of the statutory duty of care CaviTAU is a non-load-forming additive method.

Structure and appearance of a Jaw ostitis / NICO

NICO is an insufficient supply in the form of a metabolic disorder that leads to greasy-degenerative bone resolutions. In general, deer NICO represents as greasy lumps that are easy to spoon from the medullary canal of the jawbone. These degenerate fat cells in NICO-areas form inflammatory messenger substances (cytokines / chemokines) that affect other organs and may be associated with inflammatory joint disorders, breast cancer, Hashimoto’s, multiple sclerosis and other tumors there.

5 Myths About the Brain Debunked


Here at Advanced Rejuvenation I deal with the brain every day. Because of that, we also help patients who have legitimate brain issues. That said, we hear a lot of myths spreading about the brain. Are men and women really wired differently? Do we only use a small percentage of our brain? Are creative people and analytical people different because the use one part of their brain more? Do substances like alcohol kill your brain cells? Does introducing your child to classical music make him or her smarter?

These are all questions we hear and we thought we’d address rumors and set the record straight. Here is what we know not to be true:

Only a Certain Amount (10%) of Your Brain is Used

10 is the magical number circulating in society—10% is all we use of our brains. This is incorrect. Our brain is a complex organ that develops over several years. While not 100% of our brain is used at one time, several parts of the brain are working together at once, and it’s certainly more than 10 %.

It’s the Left Brain vs. the Right Brain

The thought that some people’s personalities are defined by which side of their brain they use more is simply incorrect. The idea that creative people act with more of the right side of their brain and that analytical people act more using the left side of their brain, isn’t right. In fact, both sides of the brain work whether a person is reading literature or solving a mathematic equation.

Male and Female Brains Are the Reason they Behave Differently

Similarly to the thought that “left brainers” are different from “right brainers,” it is thought that men’s brains work differently than women’s. Hence the “Men are from Mars, Women are from Venus” phrase that baby boomers have been toting around for decades. Sorry to burst your bubbles, but this isn’t true. While the hormones secreted in the brain may be different, and that during the developmental period there are some changes that differ, the adult male and female brain differences do not account for any difference in behaviors between the sexes.

Classical Music Makes You Smarter

This is a myth that came about in the 1950s and became really popular in the 1990s. A high school teacher allowed her students to listen to Mozart before an exam and noted that the students had scores significantly higher after listening to this composer. Since then, there has been a frenzy of parents pushing their children to listen to classical music in hopes that it will increase their IQ. While learning an instrument does help an individual over time, simply listening to the music will not help a person develop any kind of super human intelligence.

Alcohol Damages Your Brain Cells

While alcohol does have an effect on your brain cells, it doesn’t kill them. If it did, well, it’d kill you too. What alcohol does is that it affects the dendrites in the brain. Dendrites are found at the end of the neurons in your brain and so when they are damaged, so are you communication abilities. Long-term abuse to alcohol can lead to alcohol-related dementia and Wernicke-Korsakoff Syndrome. So no, having a cold beer or a martini after a long day now and then won’t harm your brain long term, but be careful in making it a habit.

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Throat infection Tourette’s link | Tic’s may be caused by Strep infections as well as OCD


There is growing evidence that a common childhood throat infection increases the risk of neurological disorders such as Tourette’s syndrome.

Scientists found children with such disorders were twice as likely to have had recent streptococcal infections than their healthy peers.

Researchers at Seattle’s Center for Health Studies suggest the body’s response to the infection may be key.

But they tell the journal Pediatrics that it is just one potential trigger.

 We’ve found more tantalising clues about possible connections between childhood infections and certain disorders 
Dr Robert Davis, lead researcher

OCD is more commonly associated with adults, but the researchers say it affects around 1 to 2% of school-age children – and transient tics can affect 10 to 25% of primary school age children.

Tourette’s – a neurological disorder characterized by tics, involuntary vocalization, and, in some cases, the compulsive utterance of obscenities – affects around one in every 100 children to some degree.

Scientists had suspected there may be a link between the streptococcal infection and neurological disorders.

It has been suggested that the body’s natural response to infection, where particular antibodies are produced and directed to parts of the brain, might be linked in some way to these disorders.

However, it is not clear why most of the millions of children who have bacterial throat infections each year do not develop such disorders.


The team from the Group Health Center for Health Studies in Seattle aimed to assess the strength of the link between strep infections and the incidence of neurological disorders.

They looked at 200 children aged four to 13 diagnosed with a neurological disorder between 1992 and 1999, and compared them with healthy children in the same age group.

Children with Tourette’s, OCD or a tic disorder were more than twice as likely to have had at least one streptococcal infection in the three months before symptoms of their disease emerged.

And incidence of the disorders was more than three times as common among patients who had had two or more streptococcal infections in the year before the onset of their disease.

Dr Robert Davis, who led the study, said: “There are likely a number of different causes for these conditions, which often show up first in childhood or adolescence.

“Following a number of different leads from past research, we’ve found more tantalising clues about possible connections between childhood infections and certain disorders.

“However, our findings certainly don’t suggest that there is any immediate need for a change in medical – or parental – practice.”

He stressed that much more research was needed before advice could be given to parents and doctors in a bid to reduce the occurrence of childhood neurological disorders.

But he added: “Right now, this is all still in the research stage.

“We still don’t know if treatment with common antibiotics helps prevent these neurological conditions that might follow strep throat, or reduce their severity, or shorten their duration if they do occur.”

The researchers say a person’s genes may play a critical role, with infection acting as a trigger.

The UK’s Obsessive Compulsive Disorder Centre says streptococcal infection is one of several suggested causes for the condition, because of the potential damage caused by antibodies to neurotransmitters in the brain.

It adds: “Investigations into the impact of throat infection on the malfunctioning area of the brain identified with OCD are looking promising but are, as yet, inconclusive.”

Comment: I see so many cases of neurological disorders in my practice that began after they had an infection. I believe that besides strep there are viral and other bacteria that can contribute to the auto immune complication this article talks about.

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Testimonial for 60 years of balance, vertigo and anxiety treated with FCR and Functional.Neurology


I want to…help Dr. Lieurance, D.C. promote his unique therapy with functional neurology. For me to see the changes in balance and the resulting calming effect is amazing to me. After living with this for 60 years, I find it phenomenal that my brain is able to make the changes that it is: brain neuroplasticity is a heavy player in research. I am glad I am living proof that “old dogs CAN learn new tricks”. The improvement in my quality of life continues to surprise me—as I never knew it could be this way—I just had adapted to what I knew as “normal”. Now people invading my personal space is not as overwhelming and threatening. I don’t get nearly as upset if someone bumps into me, or touches me. No longer do I feel like I am losing my balance when I turn quickly, go up or down stairs or make quick movements. My sense of security is improving as I am not having to monitor every movement, I am enjoying exercise more. Eating is becoming more reasonable, as I am not as likely to eat to calm my stomach, as it is not as constantly upset (think vertigo nausea).
This is not traditional vestibular therapy: it is very skilled/specialized and individualized—no cookbook methods here. Dr.  Lieurance has had extensive training in functional neurology, and returns to be a lead in grand rounds 2 times a year where he trained. I have always avoided traditional vestibular therapy as I felt it would make me worse. Sensory processing therapy which would have been more appropriate is not readily available in the valley for adults. I feel I have found a gold mine in Dr.  Lieurance’s practice, and my therapist, Paul who is an AIS specialist is fantastic. I want to get the word out so others can benefit as well.”



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